Miltenyi, 130-138-912, Human Noggin, research grade

Name: Human Noggin, research grade
Brand: Miltenyi
SKU: 130-138-912

Size:10 µg

Catalog Number: 130-138-912

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Category

Alkaline Phosphatase-Conjugated Secondary Antibodies

Pack Size10 µg

TagsMACS Cell Culture and Stimulation Cytokines and growth factors Premium and research grade

Description

Biological activity

Background information
Noggin is a disulfide-linked homodimer that acts by binding members of the TGF-β family, and consequently blocks their ability to signal through their receptors. Noggin plays a crucial role in regulating developmental processes by inhibiting the signaling pathway of bone morphogenetic protein 4 (BMP-4), as well as other BMPs. During embryogenesis Noggin is produced by the dorsal mesoderm and is important for the correct bone morphology and neural tissue formation. Mutations in the Noggin-coding gene (NOG) are associated with several bone diseases. The sequence of Noggin protein shows high homology across several species.

Overview
Human Noggin is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications

General

Determination method	Inhibition of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells
Research grade	≥ 6.7×104 U/mg

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