Miltenyi, 130-138-919, Human DKK-1, research grade

Biological activity

Background information
Dickkopf-1 related protein (DKK-1) is a member of the DKK family, which also includes DKK-2, DKK-3 and DKK-4. It was initially identified as an important embryogenic factor, especially for the development of the head. The effects of DKK-1 are mainly based on its role as negative regulator of the Wnt signally pathway, by forming complexes with LDL-receptor-related protein 6. High expression of DKK-1 has been found during mesenchymal development, and is critical for limb and bone formation, but also cardiogenesis. TNF-α plays a central role in DKK-1 induction, during arthritis, and blood levels of DKK-1 increase during multiple myeloma. DKK-1 acts also as negative regulator of neuronal survival and neural crest formation.

Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Overview
DKK-1 stands for Dickkopf-1 related protein. Human DKK-1 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.