Miltenyi, 130-138-923, Human IL-11, research grade

Name: Human IL-11, research grade
Brand: Miltenyi
SKU: 130-138-923

Size:10 µg

Catalog Number: 130-138-923

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Category

Human Primary Cells

Pack Size10 µg

TagsMACS Cell Culture and Stimulation Cytokines and growth factors Premium and research grade

Description

Biological activity

Background information
Interleukin 11 (IL-11) is a multifunctional cytokine belonging to the IL-6 family. It is found in various organs and tissues and is secreted by mesenchymal cells including fibroblasts, stromal cells, osteoclasts and epithelial cells. The IL-11 receptor is a heterodimeric protein expressed by different hematopoietic lineages such as megakaryocytes, erythroid and myeloid progenitors. In combination with other cytokines (IL-4, IL-3 and SCF), IL-11 regulates several hematopoietic processes, including megakaryocyte maturation.
IL-11 activates certain B and T cells and plays a role in primary and secondary immune responses as a modulator of autoinflammation in favor of Th2 polarization and allergic reactions. IL-11 is also involved in the regulation of osteoclast differentiation and blastocyst implantation. IL-11 is being investigated for the treatment of osteoporosis, thrombocytopenia and inflammatory conditions.

Overview
Human IL-11 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications

General

Determination method	Ability to induce alkaline phosphatase production in a HEK293 reporter cell line
Research grade	≥ 1×107 U/mg

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