Miltenyi, 130-138-947, Human IL-34, research grade

Biological activity

Background information
Interleukin 34 (IL-34) is a four-helical homodimeric protein that does not belong to any previously identified cytokine family. It is expressed by various tissues in response to inflammatory stimuli. Notably, IL-34 shares structural homology with M-CSF and signals through the colony stimulating factor receptor 1, and induces myeloid cell expansion and differentiation, similar to other CSFs (G-CSF, M-CSF and GM-CSF). IL-34 promotes monocyte survival and macrophage proliferation, and plays a role in hematopoietic differentiation in the bone marrow, inducing macrophage colony-forming units and promoting osteoclast differentiation, adhesion, and proliferation. A role of IL-34 in the development of myeloid compartments, especially dendritic cells and monocytes, but also Langerhans cells and microglia, is under investigation. Mouse IL-34 shares 71% protein sequence identity with human IL-34.

Overview
Human IL-34 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.