Miltenyi, 130-138-949, Human IL-5, research grade

Biological activity

Background information
Interleukin 5 (IL-5), also known as eosinophil differentiation factor (EDF), belongs to the hematopoietic family of cytokines, along with IL-3 and GM-CSF, whose receptors share the common cytokine receptor β-chain. IL-5 is secreted by T helper cells, mast cells, and eosinophils and primarily acts as a key hematopoietic growth factor for the proliferation and activation of eosinophils, but also promotes the secretion of immunoglobulins by B cells, and the generation of cytotoxic T cells. Through the activation of eosinophils, IL-5 mediates several allergic diseases, but it is also involved in parasitic infections and tumor development.

Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Overview
IL-5 stands for interleukin 5. Human IL-5 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.