Description
Background information
Survivin 1, also known as BIRC5, is an inhibitor of apoptosis and is present during normal fetal development, but disappears in most differentiated adult tissues.
The protein is highly expressed in most cancer types and shows an enhanced expression in most human cancers, including melanoma.
The overexpression of Survivin 1 in malignant tissues, as well as the beneficial effect on tumor growth, makes this protein an attractive candidate for immunotherapeutic strategies.1,2
Applications
The MACS GMP PepTivator Survivin 1 is used for in vitro stimulation of Survivin 1-specific effector and memory T cells.
Due to the strong expression of Survivin 1 in various cancer types, the adoptive transfer of Survivin 1-specific T cells or the vaccination with Survivin 1-pulsed dendritic cells represent a promising tool for immunotherapeutic approaches.
This product has not yet been tested in conjunction with the CliniMACS Cytokine Capture System (IFN-gamma).
Quality statement
MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
Disclaimer
MACS GMP Products are for ex vivo cell processing only, and are not intended for human in vivo applications. For regulatory status in the USA, please contact your local representative.
Overview
The MACS GMP PepTivator Survivin 1 is a peptide pool that consists mainly of 15-mer peptides. It has been developed for efficient in vitro stimulation and subsequent isolation of Survivin 1-specific CD4+ and CD8+ T cells.
