Description
Background information
Viral transduction of suspension cells using retroviral vectors is often inefficient and requires the use of transduction enhancers. MACS GMP Vectofusin-1 is a fully synthetic, non-toxic, cationic amphipathic peptide with viral transduction enhancing capacity, enabling higher transduction levels with low amounts of retroviral vector. MACS GMP Vectofusin-1 promotes the entry of several retroviral pseudo-types into target cells when added to the culture medium.
Applications
- Enhancement of lentiviral transduction
- Enhancement of retroviral transduction
Quality statement
MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
Disclaimer
CR/GMP products are for ex vivo cell processing only, and are not intended for human in vivo applications. CR/GMP products are designed, manufactured and tested under an ISO 13485 quality management system and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials. The manufacturing and testing of CR/GMP products of biological origin are in compliance with EP chapter 5.2.12 for “Raw materials of biological origin for the production of cell-based and gene therapy medicinal products”.
Disclaimer
MACS GMP Products are for ex vivo cell processing only, and are not intended for human in vivo applications. For regulatory status in the USA, please contact your local representative.
Overview
MACS GMP Vectofusin-1 is a non-toxic histidin-rich amphipathic peptide which exerts as viral transduction enhancer. Unlike other transduction enhancers, it is not dependent on immobilization of target cells and therefore compatible with automated processes.
