Description
Features
- Weldable tubing from supplement bag to basal medium bag ensures simplified handling
- Media designed and optimized for efficient expansion of hPSCs
- Lot-to-lot consistency ensured by xeno-free media composition and standardized manufacturing procedures
Bag Format
The iPS-Brew GMP Medium offered in bag format enables a fully closed system for clinical cell manufacturing. This design enhances safety and regulatory compliance, minimizes contamination risks and simplifies handling by allowing direct connection between supplement bag and basal medium bag through weldable tubing. Moreover, the supplement in bag is specially formulated with TGF-β1 to ensure optimal cell culture performance.
Optimized for use with the CliniMACS Prodigy ACC process, the GMP-compliant, xeno-free medium ensures reliable and scalable stem cell expansion with bioreactors at clinical settings.
Available Formats
The medium is available in two formats: in bag for automated closed workflows (e.g. CliniMACS Prodigy or bioreactors) and in bottle for manual workflows.
1. iPS-Brew GMP Medium, 2000mL (bag) (170-076-339)
- 2000 mL iPS-Brew GMP Basal Medium in bag
- 20 mL supplement in bag containing TGF-β1
Simplified handling, is ensured by tube-tube connection via weldable tubing from supplement bag to basal medium bag.
Enables seamless connection to bioreactors for manufacturing of hPSCs
2. iPS-Brew GMP Medium, 500 mL (bottle)
- iPS-Brew GMP Basal Medium, 500 mL in bottle (170-076-317)
- iPS-Brew GMP Supplement R, 10 mL in vial (170-076-318)
Requires addition of recombinant human TGF-β1 (170-076-166)
Applications
- Designed for maintenance and expansion of hPSCs and embryonic stem cells (ESCs)
- Optimized both for manual and automated workflows including CliniMACS Prodigy ACC process and bioreactor-based manufacturing
Quality statement
MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
Disclaimer
MACS GMP Products are for ex vivo cell processing only, and are not intended for human in vivo applications. For regulatory status in the USA, please contact your local representative.
Overview
iPS-Brew GMP Medium is a GMP-compliant, xeno-free and serum-free formulation designed to support the long-term growth and maintenance of undifferentiated human pluripotent stem cells (hPSCs) under feeder-free conditions. Based on the proven research-grade StemMACS iPS-Brew XF (130-104-368), this medium enables a seamless transition from research to clinical manufacturing while ensuring optimal cell growth.
Available in bag and bottle formats to support both automated and manual workflows.
