Description
MACS GMP Nuclease A is a recombinant endonuclease from Serratia marcescens that efficiently degrades DNA and RNA during the production of viral vectors, cell and gene therapies, and biologics.
Functionality assay: ≥ 250 U/μL
Source: E. coli
Purity: ≥ 99 %
Composition: MACS GMP Nuclease A is supplied in 20 mM Tris-HCl (pH 8.0), 2 mM MgCl2, 20 mM NaCl, 50 % (v/v) glycerol
Endotoxin content: ≤ 0.25 EU / 1000 U as determined by kinetic Limulus Amebocyte Lysate (LAL) assay (Pharmacopoeia Europaea (Ph. Eur.)).
Sterility: Sterility of the bottled product is tested according to Ph. Eur.
Quality statement
MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
Disclaimer
MACS GMP Products are for ex vivo cell processing only, and are not intended for human in vivo applications. For regulatory status in the USA, please contact your local representative.
Overview
MACS® GMP Nuclease A is a high-quality recombinant endonuclease from Serratia marcescens for the removal of nucleic acids in GMP-compliant manufacturing processes. It effectively reduces host cell DNA and RNA during the production of viral vectors, therapeutic proteins, vaccines and cell or gene therapies. Combining robust enzymatic performance with reliable quality and documentation, MACS GMP Nuclease A is an ideal choice for integration into regulated bioprocessing workflows.
