Proteintech, 13073-1-AP-150ul, ALOX15B Polyclonal antibody

13073-1-AP targets ALOX15B in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
Tested Applications
Positive WB detected in: A431 cells, HEK-293 cells, HL-60 cells, HeLa cells, MCF-7 cells
Recommended dilution
Western Blot (WB): WB : 1:500-1:3000
Background Information
In humans, there are 6 functional lipoxygenases genes. Two of them encode for arachidonic acid 12-lipoxygenating (ALOX12, ALOX12B) and two for 15-lipoxygenating enzymes (ALOX15, ALOX15B). ALOX15B has been described as the most abundant 15-lipoxygenating enzyme species in human carotid atherosclerotic lesions and to be associated with cerebrovascular symptoms. (PMID:24373925). ALOX15B has 4 isoforms produced by alternative splicing with the MW of 76, 67, 69 and 73 kDa. 13073-1-AP can also recognize the mouse Alox8 protein.