Description
20703-1-AP targets ABCB5 in WB, ELISA applications and shows reactivity with human samples.
Tested Applications
Positive WB detected in: A431 cells, HT-29 cells, Jurkat cells, K-562 cells, THP-1 cells
Recommended dilution
Western Blot (WB): WB : 1:500-1:1000
Background Information
ABCB5 is an 812 amino acid multi-pass membrane protein and belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins (PMID: 15760339). ABCB5 is an Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells(PMID: 15899824, 15205344). ABCB5 acts as a marker of stem-like cells (CSC) in several malignancies and is responsible for the resistance to doxorubicin of a subset of malignant melanomas (PubMed:24934811, 15760339). Alternate splicing results in multiple transcript variants.