Proteintech, 22234-1-AP-20ul, ADAM28 Polyclonal antibody

22234-1-AP targets ADAM28 in WB, IP, ELISA applications and shows reactivity with human, mouse samples.
Tested Applications
Positive WB detected in: mouse lung tissue, BxPC-3 cells, PC-13 cells, mouse spleen tissue
Positive IP detected in: mouse lung tissue
Recommended dilution
Western Blot (WB): WB : 1:500-1:1000
Immunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Background Information
ADAM28 belongs to a family of cell surface and secreted glycoproteins that possess both proteolytic and adhesive properties. ADAM28 is predominantly expressed by carcinoma cells in the breast carcinoma tissues as protein bands of 42 kDa and 55/57 kDa, which correspond to the active forms of ADAM28s and ADAM28m, respectively.In human non-small cell lung carcinomas and breast carcinomas, ADAM28 is overexpressed predominantly by carcinoma cells, and the expression correlates with carcinoma cell proliferation and lymph node metastasis(PMID:19601836).