Proteintech, 23909-1-AP-150ul, AFAP1L1 Polyclonal antibody

23909-1-AP targets AFAP1L1 in WB, ELISA applications and shows reactivity with human, monkey samples.
Tested Applications
Positive WB detected in: COS-7 cells
Recommended dilution
Western Blot (WB): WB : 1:500-1:1000
Background Information
Actin Filament-Associated Protein of 110 kDa (AFAP-110/AFAP1) is an adaptor protein with multiple protein binding motifs that is known to function as both an actin binding protein and a cSrc activating protein. A homology search of AFAP1 recently identified AFAP1L1 which has a similar sequence, domain structure and cellular localization. AFAP1L1 is highly expressed in human breast, colon and brain tissue. AFAP1L1 interacts with cortactin and involves the invadosomes formation. AFAP1L1 as a prognostic marker has a role in the progression of spindle cell sarcomas.