Proteintech, 23913-1-AP-150ul, AES Polyclonal antibody

23913-1-AP targets AES in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications
Positive WB detected in: DU 145 cells, HEK-293 cells, mouse skeletal muscle tissue, rat skeletal muscle tissue
Recommended dilution
Western Blot (WB): WB : 1:500-1:2000
Background Information
Amino-terminal enhancer of split (AES), belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members in order to forcefully repress the expression of other family member genes. AES can repress NFkB-regulated gene expression and is believed to have a significant role in initiating and maintaining cell differentiation events. AES has been found to suppress local invasion and intravasation through inhibition of the Notch pathway, leading to preventing the metastatic spread of endogenous tumors(PMID: 33754069).