Proteintech, 24453-1-AP-20ul, ABCG8 Polyclonal antibody

24453-1-AP targets ABCG8 in WB, ELISA applications and shows reactivity with human, rat samples.
Tested Applications
Positive WB detected in: HL-60 cells, PC-12 cells, k-562 cells
Recommended dilution
Western Blot (WB): WB : 1:500-1:2000
Background Information
ABCG8(ATP-binding cassette sub-family G member 8) and ABCG5(ATP-binding cassette protein G5) are members of the ABC transporter family and are half-type ABC transporters, which consist of six transmembrane helices and one nucleotide-binding domain. ABCG5 and ABCG8 form a heterodimer (ABCG5/ABCG8). Mutations in either ABCG5 or ABCG8 cause a genetic disorder, sitosterolemia. Patients with sitosterolemia show high plant sterol levels and develop hypercholesterolemia and atherosclerosis at a young age.(PMID: 36839356)