Proteintech, 25888-1-AP-20ul, AMHR2 Polyclonal antibody

25888-1-AP targets AMHR2 in IHC, ELISA applications and shows reactivity with human, mouse samples.
Tested Applications
Positive IHC detected in: human testis tissue, human ovary tumor tissue, mouse brain tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0
Recommended dilution
Immunohistochemistry (IHC): IHC : 1:50-1:500
Background Information
Anti-Mullerian hormone (Amh) is the key factor in the regression of the Mullerian ducts that is secreted by the Sertoli cells of the testis. As a member of the transforming growth factor β family, Amh signals through a heterodimeric receptor complex consisting of two type I and two types II serine/threonine kinases receptors (J. Klatting, et. al, 2007). On ligand binding, Type II receptors phosphorylate and activate Type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. The Amh type II receptor (Amhr2) confers the specificity and is initially expressed in the coelomic epithelium next to the Mullerian ducts in both males and females (Zhan, y. et. al, 2006).