Proteintech, 27124-1-AP-20ul, ADAM15 Polyclonal antibody

27124-1-AP targets ADAM15 in WB, ELISA applications and shows reactivity with human samples.
Tested Applications
Positive WB detected in: A549 cells, HUVEC cells
Recommended dilution
Western Blot (WB): WB : 1:500-1:3000
Background Information
ADAM15, a member of the ADAM (a disintegrin and metalloprotease) family, is a membrane protein containing both protease and adhesion domains and may be involved in tumor invasion and metastasis (PMID:15756594). It is also named as MDC15. ADAM15 is required for the activation of the FAK and Src pathways to generate apoptosis resistance in response to apoptotic signalling or cell stress (PMID: 11741929). ADAM15 is processed during epididymal maturation and acrosome reaction and that it may play a role during sperm-egg binding. Jurkat and testicular cells expresses the precursor ADAM15 of 110 kDa, as well as the ADAM15 processing form, consisting of about 75-85 kDa (PMID:18390692). ADAM15 has some isoforms with the calculated molecular mass of 55~92 kDa.