Proteintech, 27973-1-AP-20ul, ALKBH1 Polyclonal antibody

27973-1-AP targets ALKBH1 in WB, ELISA applications and shows reactivity with Human samples.
Tested Applications
Positive WB detected in: A549 cells
Recommended dilution
Western Blot (WB): WB : 1:500-1:1000
Background Information
Two RNA m6A demethylases, FTO and ALKBH5, have been identified since 2011, with both capable of removing the methyl group of m6A on poly-adenylated RNA through an iron-dependent oxidative demethylation mechanism. ALKBH1 as a RNA demethylase that mediates removal of the methyl group from N1-methyladenosine (m1A) in tRNA. ALKBH1 can tune translation initiation and elongation by regulating the cellular levels of tRNAiMet and the association of other ALKBH1 target tRNAs to polysomes, thereby affecting protein synthesis.