Proteintech, 29948-1-AP-20ul, ADAM17 Polyclonal antibody

29948-1-AP targets ADAM17 in WB, IF, ELISA applications and shows reactivity with human, mouse samples.
Tested Applications
Positive WB detected in: HUVEC cells, MCF-7 cells, SKOV-3 cells, RAW 264.7 cells
Recommended dilution
Western Blot (WB): WB : 1:2000-1:16000
Background Information
The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor (PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092).