Proteintech, 31569-1-AP-20ul, AIF1L Polyclonal antibody

31569-1-AP targets AIF1L in WB, IF-P, ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications
Positive WB detected in: HEK-293 cells, MCF-7 cells, mouse kidney tissue, rat kidney tissue
Positive IF-P detected in: mouse kidney tissue
Recommended dilution
Western Blot (WB): WB : 1:1000-1:4000
Immunofluorescence (IF)-P: IF-P : 1:50-1:500
Background Information
AIF1L is a homolog to the allograft inflammatory factor 1 (AIF1 or IBA1), sharing up to 60% sequence homology. Previous work could demonstrate that AIF1L and AIF1 show actin bundling and cross-linking function, co-localization, and-sedimentation with F-actin. More recently, increased expression levels for AIF1L were reported in cases of breast cancer and functionally related to increased proliferation rates via upregulation of cyclin D1.