Proteintech, 31686-1-AP-20ul, ALAD Polyclonal antibody

31686-1-AP targets ALAD in WB, ELISA applications and shows reactivity with human samples.
Tested Applications
Positive WB detected in: Jurkat cells, U-251 cells
Recommended dilution
Western Blot (WB): WB : 1:2000-1:12000
Background Information
Delta-aminolevulinic acid dehydratase (ALAD) is also named as Porphobilinogen synthase. ALAD, encoded by the moonlighting gene ALAD, not only participates in the second step of heme biosynthesis, but also inhibits the 26S proteasome (PMID: 35318110). ALAD is involved in tumor progression. For example, ALAD2 allele (ALAD polymorphism) is related to an increased risk for meningioma, and downregulation of ALAD is related to poor prognosis of patients with breast cancer (PMID: 16140629, PMID: 28403546).