Proteintech, 33887-1-AP-20ul, ANG4 Polyclonal antibody

33887-1-AP targets ANG4 in WB, ELISA applications and shows reactivity with mouse samples.
Tested Applications
Positive WB detected in: mouse colon tissue
Recommended dilution
Western Blot (WB): WB : 1:500-1:2000
Background Information
Mouse ANG4 (Angiogenin-4) is a member of the angiogenin (RNase A) family, primarily expressed and secreted specifically by intestinal Paneth cells. As a key effector molecule of intestinal innate immunity, ANG4 is an antimicrobial protein possessing ribonuclease (RNase) activity. It exerts direct bactericidal effects by cleaving bacterial tRNA-particularly in Gram-positive bacteria-thereby inhibiting their protein synthesis. This protein plays a central role in maintaining intestinal microbial homeostasis and defending against pathogen invasion. Its expression is regulated by the gut microbiota and immune signals (such as IL-22), making ANG4 an important model protein for studying host-microbe interactions and mucosal immunity.