Proteintech, 66628-1-Ig-100uL, ACTN4 Monoclonal antibody

66628-1-Ig targets ACTN4 in WB, IHC, IF, IP, ELISA applications and shows reactivity with human, mouse, rat samples.
Background Information
ACTN4 (alpha actinin 4) is a ubiquitous actin-binding protein that cross-links actin filaments into bundles to form filopodia, and has a crucial role in cytoskeletal organization. ACTN4 is colocalized with actin stress fibers and is dispersed in the cytoplasm and in the nucleus. Increased levels of ACTN4 have been associated with cancer metastasis, indicating its implication in cancer cell migration and metastasis. Defects in ACTN4 cause glomerular disease. This antibody recognizes 105 and 80 kDa of endogenous ACTN4 protein in various lysates. (22370640, 10700177)