Proteintech, 67955-1-Ig-150ul, ABCC5 Monoclonal antibody

67955-1-Ig targets ABCC5 in WB, ELISA applications and shows reactivity with Human, Rat samples.
Tested Applications
Positive WB detected in: HepG2 cells, U2OS cells, HEK-293 cells, HeLa cells, K-562 cells, HSC-T6 cells
Recommended dilution
Western Blot (WB): WB : 1:5000-1:50000
Background Information
ABCC5, also named as MOAT-C, pABC11, SMRP, and MRP5, belongs to the ABC transporter superfamily, ABCC family, and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump that can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Since it is glycosylated, the apparent molecular weight of ABCC5 could be variable, ranging from 161 kDa to 200 kDa (PMID: 10893247; PMID: 15897250; PMID: 31338999).