Proteintech, 83317-5-RR-100ul, ADRB2 Recombinant monoclonal antibody

83317-5-RR targets ADRB2 in IF/ICC, ELISA applications and shows reactivity with human samples.
Tested Applications
Positive IF/ICC detected in: A431 cells
Recommended dilution
Immunofluorescence (IF)/ICC: IF/ICC : 1:200-1:800
Background Information
Beta-2 adrenergic receptor (ADRB2), a member of the G protein-coupled receptor (GPCR) family, binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. ADRB2 is directly linked to one of its final effectors, the class C L-type Ca2+ channel, Cav1.2 (PMID: 11441182). This receptor-channel complex also contains a G protein, an adenylyl cyclase, cyclic adenosine monophosphate-dependent protein kinase (PKA), and a counteracting phosphatase, PP2A. Different polymorphic forms, point mutations, and/or downregulation of the gene of ADRB2 are associated with nocturnal asthma, obesity, and type 2 diabetes.