Description
83570-4-RR targets ANAPC10 in WB, IF/ICC, ELISA applications and shows reactivity with human samples.
Tested Applications
Positive IF/ICC detected in: HeLa cells
Recommended dilution
Immunofluorescence (IF)/ICC: IF/ICC : 1:125-1:500
Background Information
The anaphase promoting complex/cyclosome (APC/C) is a cell cycle-regulated multimeric E3 ubiquitin ligase assembled from 13 individual subunits. The anaphase promoting complex subunit 10 (APC10) is a core subunit of APC/C that is highly conserved in humans. APC10 genetically and physically interacts with a series of subunits of the APC/C and is necessary for the ubiquitination activity of APC/C by enhancing the affinity of the APC/C for its substrate.