Proteintech, 83759-4-RR-20ul, AGER/RAGE Recombinant monoclonal antibody

83759-4-RR targets AGER/RAGE in WB, IF-P, ELISA applications and shows reactivity with rat samples.
Tested Applications
Positive WB detected in: rat lung tissue
Positive IF-P detected in: rat brain tissue
Recommended dilution
Western Blot (WB): WB : 1:2000-1:10000
Immunofluorescence (IF)-P: IF-P : 1:200-1:800
Background Information
Advanced glycosylation end product-specific receptor (AGER, also known as RAGE) is a member of the immunoglobulin superfamily of cell surface receptors, which interacts with distinct families of ligands, mediating diverse functions in a broad array of cell types including cellular migration, proliferation, survival and apoptosis (PMID: 12645002; 17425919). It senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PMID: 19910580; 28627626). It interacts with distinct molecules implicated in homeostasis, development, inflammation, and certain diseases such as diabetes and Alzheimer's disease (PMID: 26253613; 31079281).