Proteintech, 84011-6-RR-100ul, ABR Recombinant monoclonal antibody

84011-6-RR targets ABR in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications
Positive WB detected in: SH-SY5Y cells, mouse brain tissue, SW480 cells, U-251 cells, U-87 MG cells, rat brain tissue
Recommended dilution
Western Blot (WB): WB : 1:5000-1:50000
Background Information
ABR (Active breakpoint cluster region-related protein) is the only protein known in humans and mice to share high homology with BCR (68% amino acid identity). BCR(Breakpoint cluster region) gene was originally identified due to its involvement in a specific chromosomal translocation that causes the development of chronic myeloid leukemia and a subset of acute lymphoblastic leukemia. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. (PMID: 17116687, PMID: 37507586)