Proteintech, 85974-3-RR-100ul, ADAMTS13 Recombinant monoclonal antibody

85974-3-RR targets ADAMTS13 in applications and shows reactivity with human samples.
Tested Applications
Positive WB detected in: human plasma
Recommended dilution
Western Blot (WB): WB : 1:500-1:2000
Background Information
ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13) is a zinc-dependent metalloproteinase that contains multiple domains, such as the signal peptide, propeptide, metalloproteinase domain, disintegrin-like domain, and TSP-1 domain, among others. The primary function of ADAMTS13 is to specifically cleave the ultra-large multimers of von Willebrand factor (vWF), preventing excessive platelet aggregation and the formation of microvascular thrombi.
Deficiency of ADAMTS13 is closely associated with thrombotic thrombocytopenic purpura (TTP), a severe disease characterized by thrombocytopenia, microvascular thrombosis, and tissue damage. Additionally, reduced ADAMTS13 activity is also linked to diseases such as myocardial infarction and stroke.