Proteintech, 86853-1-RR-20ul, ABCB10 Recombinant monoclonal antibody

86853-1-RR targets ABCB10 in WB, ELISA applications and shows reactivity with human samples.
Tested Applications
Positive WB detected in: Jurkat cells, K-562 cells, Raji cells, SKOV-3 cells, COLO 205 cells
Recommended dilution
Western Blot (WB): WB : 1:1000-1:6000
Background Information
ABCB10 (also known as ABC-me or M-ABC2) is an inner-mitochondrial-membrane ATP-binding cassette transporter that forms homodimers with its nucleotide-binding domain facing the matrix. ABCB10 is now recognized as a multifunctional protein that couples mitochondrial export activity to cellular antioxidant defence. During red-cell development it stabilises the iron importer mitoferrin-1 (Mfrn1), thereby sustaining heme synthesis, whereas in cardiac and other non-erythroid tissues it attenuates oxidative damage by limiting mitochondrial ROS accumulation. PMID: 22884976