Proteintech, 87231-1-RR-100ul, ACLY Recombinant monoclonal antibody

87231-1-RR targets ACLY in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications
Positive WB detected in: HeLa cells, Jurkat cells, K-562 cells, MCF-7 cells, A549 cells, mouse brain tissue, rat brain tissue
Recommended dilution
Western Blot (WB): WB : 1:2000-1:10000
Background Information
ACLY(ATP-citrate synthase) is also named as ACL. It is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA. ACLY serves as not only a target in oxygenated cells for suppression of lipid synthesis and histone acetylation, but also as a susceptible target in hypoxic cells to restore inhibition of glycolysis. In nonsmall cell lung carcinoma and hepatocellular carcinoma, ACLY is overexpressed compared with normal parenchyma suggesting that ACLY may represent a common target among highly malignant tumors(PMID:19795461).