Description
87444-1-RR targets ANKRD2 in WB, ELISA applications and shows reactivity with human, mouse, rat, pig samples.
Tested Applications
Positive WB detected in: mouse skeletal muscle tissue, human skeletal muscle tissue, pig skeletal muscle tissue, rat skeletal muscle tissue
Recommended dilution
Western Blot (WB): WB : 1:5000-1:50000
Background Information
ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family. Expression of MARPs is induced in response to physiologic stress, injury, and hypertrophy. Together with Ankrd1/CARP and DARP, ANKRD2 are members of the MARP mechanosensing proteins that form a complex with titin (N2A)/calpain 3 protease/myopalladin. Ankrd2 is thought to have dual, structural and signaling roles, and could link the elastic I-band region as a stress sensor for transcriptional control in the nucleus.