Stemcell, 100-0246, Dorsomorphin

Dorsomorphin inhibits the bone morphogenetic protein (BMP) pathway by targeting the type I BMP receptors activin receptor-like kinase (ALK) 2, ALK3, and ALK6. It is also a potent inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM) but does not significantly inhibit structurally related kinases such as ZAPK, SYK, PKCθ, PKA, or JAK3 (Bain et al., Yu et al.).

DIFFERENTIATION

· Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Morizane et al., Zhou et al.).

· Promotes differentiation of cardiomyocytes from mouse and human pluripotent stem cells (Hao et al., Kattman et al.).

· Promotes differentiation of adipocytes and suppresses osteogenic differentiation of osteoblasts from human mesenchymal cells (Kim et al.).