Stemcell, 100-0261, Verteporfin

Name: Verteporfin
Brand: Stemcell
SKU: 100-0261

Size: 5 mg, YAP1 inhibitor

Catalog Number: 100-0261

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size5 mg

TagsProduct Types Small Molecules

Description

Verteporfin is a benzoporphyrin derivative that inhibits autophagosome formation by directly targeting and modifying p62, a scaffold protein that targets polyubiquitinated proteins for degradation (Donohue et al.). Verteporfin also disrupts YAP-TEAD interactions by enhancing trypsin cleavage of YAP (EC₅₀ = 100 nM; Brodowska et al.; Liu-Chittenden et al.).

CANCER RESEARCH

· Inhibits the growth, proliferation, and viability of human retinoblastoma cells (Brodowska et al.).

· Inhibits self-renewal in cancer stem cells with high YAP1 and ALDH1 levels (Song et al.).

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Stemcell, 100-0261, Verteporfin

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