Stemcell, 100-0266, GSK621

Name: GSK621
Brand: Stemcell
SKU: 100-0266

Size: 5 mg, AMPK agonist

Catalog Number: 100-0266

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size5 mg

TagsProduct Types Small Molecules

Description

GSK621 is a specific agonist of AMP-activated protein kinase (AMPK; Sujobert et al.)

CANCER RESEARCH

· Increases AMPKα T172 phosphorylation, a marker of AMPK activation, in acute myeloid leukemia (AML) cells and primary AML samples (Sujobert et al.).

· Displays selective cytotoxicity (IC₅₀ = 13 - 30 μM) by activating autophagy via the eIF2ɑ signaling pathway independent of mTORC1 activation in AML cell lines but not in normal hematopoietic progenitor cells (Sujobert et al.).

· Inhibits human melanoma cell survival and proliferation (Chen et al.).

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Stemcell, 100-0266, GSK621

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