Stemcell, 100-0270, SBI-0206965

Name: SBI-0206965
Brand: Stemcell
SKU: 100-0270

Size: 10 mg, ULK1 and ULK2 kinase inhibitor

Catalog Number: 100-0270

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size10 mg

TagsProduct Types Small Molecules

Description

SBI-0206965 is an inhibitor of the autophagy initiator kinases ULK1 and ULK2 (IC₅₀ = 108 nM and 711 nM, respectively; Egan et al.). SBI-0206965 is also a potent inhibitor of AMP-activated protein kinase (AMPK), a positive regulator of autophagy (Dite et al.).

CANCER RESEARCH

· Synergizes with mTOR inhibition to induce apoptosis and cell death in tumor cells (Egan et al.).

· Suppresses autophagy induced by mTOR inhibition (Egan et al.).

· Suppresses prosurvival autophagic responses in tumor cells through AMPK and ULK1 inhibition (Dite et al.).

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Stemcell, 100-0270, SBI-0206965

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