Stemcell, 100-0519, Cl-Amidine

Cl-Amidine is a protein-arginine deiminase (PAD) inhibitor that irreversibly inactivates four subtypes of PAD (kinact/Ki = 37,000/PAD1, 1,200/PAD2, 2,000/PAD3, and 13,000/PAD4 M-1min-1; Knuckley et al.; Luo et al.; Slack et al.) by modifying the enzyme’s active site. This product is supplied as the hydrochloride salt of the molecule.

IMMUNOLOGY

· Inhibits neutrophil extracellular traps formation in neutrophils (Knight et al.).

· Prevents hypercitrullination of histone H3 in neutrophils (Knight et al.).

CANCER RESEARCH

· Exhibits cytotoxic effects toward human leukemia (IC50 = 0.25 μM), breast (IC50 = 0.05 μM), and colon (IC50 = 1 μM) cancer cell lines (Slack et al.).