Stemcell, 100-0548, 3,3',5-Triiodo-L-thyronine (Sodium Salt Hydrate)

3,3',5-Triiodo-L-thyronine is a thyroid hormone, which is converted from the prohormone thyroxine via deiodination (Misiti et al.). 3,3',5-Triiodo-L-thyronine binds thyroid hormone receptors TRα and TRβ (Kd = 0.06 nM for both thyroid hormone receptors; Sandler et al.), and is essential for growth and differentiation of a variety of cell types (Misiti et al.; Shiohara et al.). 3,3',5-Triiodo-L-thyronine inhibits leucine transport by pituitary cells (IC50 = 2 μM; Yan & Hinkle). This product is supplied as the sodium salt hydrate form of the molecule.

DIFFERENTIATION

· Promotes pancreatic β cell differentiation from human pluripotent stem cells (Pagliuca et al.).

CANCER RESEARCH

· Inhibits the proliferation of pancreatic adenocarcinoma (Michienzi et al.).