Stemcell, 100-0560, L-Buthionine-(S,R)-sulfoximine

L-Buthionine-(S,R)-sulfoximine is a potent and irreversible inhibitor of γ-glutamylcysteine synthetase (γGCS; Ki < 100 μM) and used to deplete glutathione and sensitize cells to anticancer agents (Griffith; Hibi et al.; Lewis-Wambi et al.; Marengo et al.). γGCS is a rate-limiting enzyme in the glutathione (GSH) biosynthetic pathway and essential for glutathione homeostasis and cell survival (Hibi et al.).



CANCER RESEARCH

· Decreases glutathione levels and elevates reactive oxygen species production, leading to apoptosis in neuroblastomas (Marengo et al.).

· Predisposes estrogen-independent human breast cancer cells to estradiol-induced apoptosis (Lewis-Wambi et al.).