Stemcell, 100-0565, Mifepristone

Mifepristone is a progesterone and glucocorticoid receptor antagonist (Ki = 0.64 and 0.1 nM, respectively; Attardi et al.; Song et al.; von Geldern et al.). It has been reported that Mifepristone is used in the treatment of leiomyomata, endometriosis, breast cancer, and meningioma (Mahajan et al.).

CANCER RESEARCH

· Inhibits the expressions of cyclin-dependent kinase 1 (CDK1) and cyclin-dependent kinase 2 (CDK2), leading to cell cycle arrest and apoptosis in endometrial epithelial cells and stromal cells in adenomyosis (Che et al.).

· Induces cell cycle arrest and apoptosis in antiestrogen-resistant breast cancer cells in vitro (Gaddy et al.).