Stemcell, 100-0881, Clozapine N-Oxide

Clozapine N-Oxide is an inactive metabolite of clozapine and an activator of designer receptors exclusively activated by designer drugs (DREADDs; Manvich et al.). In mice, clozapine-N-oxide is converted back to the parent compound clozapine (Manvich et al.). Clozapine-N-oxide can activate G protein-coupled receptor activities that govern behavior, perceptions, and motor functions (Manvich et al.; Martinez et al.; Urban & Roth). Clozapine is administered as an antipsychotic and has shown efficacy in reducing cognitive and psychiatric symptoms in Parkinson’s patients (Stinton et al.).

DISEASE MODELING

· Lowers striatal glutamate level in rats (Bærentzen et al.).

· Elevates glutamate level in nucleus accumbens core in mice (Scofield et al.).