Stemcell, 100-0899, Human Amyloid-β (1-42) Peptide (Trifluoroacetate Salt)

Human Amyloid-β (1-42) Peptide is a neurotoxic peptide fragment that can oligomerize to form amyloid plaques, thus contributing to the onset of Alzheimer's disease (Paradis et al.; Teplow; Wolfe). These neurotoxic peptide fragments also modulate the expression of Bcl-2 and Bax in human neurons (Paradis et al.).

NOTE: Human Amyloid-β (1-42) Peptide oligomers and fibrils are considered neurotoxic. Please contact your workplace safety committee for guidance before planning any work using Human Amyloid-β (1-42) Peptide.

DISEASE MODELING

· Induces neuronal death in human neurons in vitro and in vivo (Paradis et al.).

· Increases production of TNF-α in rat astrocytes (Hughes et al.).