Stemcell, 100-1043, DMH1

DMH1 (dorsomorphin homolog 1) is a selective inhibitor of activin receptor-like kinase 2 (ALK2; IC₅₀ = 13 - 108 nM), a type I bone morphogenetic protein (BMP) receptor (Hao et al.; Mohedas et al.). DMH1 exhibits no detectable inhibition of ALK4, ALK5, AMPK, KDR (VEGFR2), or PDGFRβ, although it inhibits ALK1 and ALK3 at nanomolar concentrations (Hao et al.; Mohedas et al.).

DIFFERENTIATION

· Induces differentiation of mouse embryonic stem cells to cardiomyocyte progenitor cells (Ao et al.).

· Induces differentiation of human induced pluripotent stem cells to SOX1 and PAX6 expressing neural precursor cells (Neely et al.).

· Dorsalizes the embryonic axis without disrupting the angiogenic process in early zebrafish embryos (Hao et al. 2010).

CANCER RESEARCH

· Suppresses non-small cell lung cancer cell growth, migration and invasion in vitro, and attenuates xenografted lung tumor growth in vivo (Hao et al. 2014).

· Inhibits chemotherapeutic drug-induced autophagy response (Sheng et al.).