Stemcell, 100-1049, Purmorphamine

Name: Purmorphamine
Brand: Stemcell
SKU: 100-1049

Size: 5 mg, Hedgehog pathway activator; Activates Smoothened (SMO)

Catalog Number: 100-1049

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Category

Differentiation Media

Pack Size5 mg

TagsProduct Portfolios Differentiation Human Pluripotent Stem Cell Research

Description

Purmorphamine is a tri-substituted purine derivative that activates the Hedgehog pathway by directly binding to and activating the Hedgehog receptor Smoothened (EC₅₀ = 1 µM). (Sinha and Chen)

DIFFERENTIATION

· Promotes differentiation of ventral spinal progenitors and motor neurons from human pluripotent stem cells (Hu and Zhang, Karumbayaram et al., Li et al.).

· Promotes differentiation of osteoblasts from human and mouse mesenchymal cells (Beloti et al., Wu et al. 2002, Wu et al. 2004).

· Inhibits differentiation and maturation of adipocytes from human mesenchymal cells (Fontaine et al.).

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Stemcell, 100-1049, Purmorphamine

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