Stemcell, 100-1050, Rapamycin

Rapamycin is a macrolide antibiotic and immunosuppressive compound that inhibits mammalian target of rapamycin (mTOR) signaling. It acts through formation of a complex with cytosolic FK-binding protein 12 (FKBP-12), which directly binds to mTOR complex 1 (mTORC1). Its immunosuppressive effects are mediated through inhibition of IL-2 signaling that is critical for T-cell proliferation and activation (Gibbons et al.; Kay et al.). Rapamycin shows antifungal activity against Candida albicans and other fungi (Vézina et al.)

CANCER RESEARCH

· Inhibits growth of MDA-MB-468 human breast cancer cells in vitro, and inhibits tumor growth in a mouse xenograft model in vivo (Akcakanat et al.).

· Induces autophagy in malignant glioma cells (Takeuchi et al.).