Stemcell, 100-1065, Anti-Human Vimentin Antibody, Clone 1A7

Clone1A7 is a mouse monoclonal antibody that reacts with human vimentin, a class III intermediate filament that is composed of α-helical regions linked into a coiled-coil protein and confers mechanical resistance in cells. Use the 1A7 clone in applications requiring detection of vimentin. It is verified for use with immunocytochemistry (ICC).

Vimentin is expressed in mesenchymal cells and mediates several functions, including cell adhesion, signaling, and migration. Vimentin filaments have been reported to interact with signaling proteins, such as Cdc42, Rac1, and the 14-3-3 family of proteins, suggesting a role in modulation and regulation of signal transduction processes. This structural protein is also involved in the LARP-6 dependent binding and stabilization of collagen mRNA during the development of tissue fibrosis. It is regarded as a marker of mesenchymal-derived cells but has been implicated in tumor detection, such as in distinguishing between some sarcomas and carcinomas.