Stemcell, 100-1125, Busulfan

Inhibit proliferation of cancer cells by creating DNA breaks and DNA crosslinks with busulfan (Iwamoto et al.). Highly potent and cell-permeable, busulfan forms interstrand crosslinks between the DNA bases guanine and adenine and between guanine and guanine (Ponti et al.). DNA breakage induced by busulfan-mediated DNA crosslinking induces senescence in cells (Chen et al.).

Busulfan has been used for:

CANCER RESEARCH

· Induces senescence through bypassing the p53-p21 (Cip1/Waf1) pathway in murine bone marrow hematopoietic cells (Meng et al.).

· Induces senescence of WI38 fibroblasts in vitro through ERK-P38 pathways (Probin V et al.).

· Inhibits the growth and viability of osteosarcoma cells (U2OS and MG63) in vitro and in orthotopic implants in mice (Mei et al.).