Stemcell, 100-1129, BMN 673

Inhibit poly ADP ribose polymerase (PARP) with BMN 673 (PARP1 IC50 = 0.57 nM; Shen et al.). BMN 673 binds to PARP in cancer cells with BRCA1, BRCA2, or PTEN mutations and prevents PARP-mediated repair of single-strand DNA breaks, leading to DNA damage (Shen et al.).

BMN 673 has been used for:

CANCER RESEARCH

· Traps PARP1 at the DNA damage site and induces cytotoxic effects in breast cancer cells (Sethy & Kundu).

· Increases the number of CD8+ T cells and NK cells, as well as production of IFN-γ and TNF-α, to inhibit growth of BRCA1-deficient murine epithelial ovarian cancer cell line BR5FVB1-Akt (Huang et al.).

· Inhibits BRCA2-associated pancreatic ductal adenocarcinoma (PDAC) growth in a PDAC murine xenograft model (Andrei et al.).