Stemcell, 100-1163, Etoposide

Inhibit proliferation of cancer cells by inhibiting topoisomerase II activity with Etoposide. Highly potent and cell-permeable, etoposide inhibits topoisomerase II (IC50 = 60.3 μM) from religating broken DNA strands by forming a complex with topoisomerase II and DNA, which leads to cell death (Wu et al.). Etoposide has also been used as a way to trigger and model cellular senescence in vitro (Bang et al.; Te Poele et al.; Teng et al.; Yang et al.).

Etoposide has been used for:

CANCER RESEARCH

· Inhibits proliferation activity of adenocarcinoma cells and human umbilical vein endothelial (HUVEC) cells (Drevs et al.).

· Inhibits growth of murine angiosarcoma cell line (ISOS-1; Ma et al.).

· Induces cellular senescence in normal and cancer cells (Bang et al.; Te Poele et al.; Teng et al.; Yang et al.).

· Supports treatment and disease modeling of small cell lung cancer (Gardneret al.; Kalemkerian et al.).