Stemcell, 100-1170, ABT-888 (Dihydrochloride)

Inhibit cancer cell growth by inhibiting poly ADP ribose polymerase (PARP) with ABT-888 (Dihydrochloride). With a high affinity for both PARP1 and PARP2 (IC50 = 5.2 and 2.9 nM), ABT-888 is inactive against sirtuin 2 (Donawho et al.). ABT-888 inhibits PARPs and prevents them from repairing DNA breaks during DNA replication, which leads to DNA damage and apoptosis (Javle & Curtin).

ABT-888 has been used for:

CANCER RESEARCH

· Inhibits the growth of Capan1 cells with BRCA 2 mutations (Cincinelli et al.).

· Inhibits colony growth of PC-3 tumors, though no effect in DU-145 tumors has been found (Barreto-Andrade et al.).